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By increasing blood sugar, melatonin might decrease the effectiveness of diabetes medications. However, other evidence suggests that taking melatonin daily does not reduce involuntary movements in these patients. Melatonin protects against experimental reflux esophagitis. Melatonin enhances the immune response to vaccination against A1 and C strains of Dichelobacter nodosus. The Effects of Multiple Sclerosis. Never try to catch up by taking two doses at once. Some early research suggests that taking melatonin in the evening might improve some symptoms of CFS, including fatigue, concentration, and motivation. The effects of melatonin premedication on propofol and thiopental induction dose-response curves: Melatonin is a hormone that helps to regulate the sleep-wake cycle. Lack of neuroprotection with pharmacological onilne in a paradigm for anticipated spinal cord lesions. Melatonin in the treatment of cancer: Evidence of melatonin synthesis and release by mast cells.