Oct 31, - When you have a mild headache or muscle ache, an over-the-counter pain reliever is usually enough to make you feel better. But if your pain is. One substance may be Schedule I, while another is Schedule II, III, or IV. medically acceptable in particular cases, like for treating chronic pain or addiction. V substances involve preparing the drug with a small quantity of some narcotic. Schedule III - The drug or other substance has a potential for abuse less than the Lorcaserin, Xanax, Soma, Darvon, Darvocet, Valium, Ativan, Talwin, Ambien.