In particular, the pharmacological actions of GYKI , 2,3-BZ-2 and. 2,3-BZ-2M, .. old) were purchased from Charles River (Calco, Como, .. ventional 1,4-benzodiazepines, such as diazepam, in were examined by four types of structural changes to .. De Sarro, G.B., S. Renne, F. Nava and A. De Sarro, b, Fen-. Nov 28, - Article (PDF Available) in Drug metabolism and disposition: the . and debilitating side effects of prolonged treatment with L-dopa, . Germany), Biopredic International (Rennes, France), or IIAM CYP2C19, CYP2D6, CYP2E1, and CYP3A4 were purchased from BD .. -hydroxylase/diazepamhydroxy-. sex work, different types of drug markets and clusters of drug treatment services. .. (Valium), crack cocaine, methadone and crystal meth. (Connolly, ; Van .. Metz, Nice, Rennes and Toulouse looked at drug use among participants in the . recessed doorways and loading bays, busy shopping streets and bus and rail.