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diazepam was significantly altered having a half-life of 37 h before and 18 h afterwards The formation of the main metabolite N-desmethyldiazepam was. Diazepam has a short half-life in dogs ( h) compared with cats (–20 h). Additionally, its active metabolite nordiazepam also has a short half-life in dogs (3 h. Diazepam is N-demethylated by CYP3A4 and 2C19 to the active metabolite In children 3 - 8 years old the mean half-life of diazepam has been reported to.

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