Valium half life metabolites journal

Macmillan Journals Ltd. . Table 1 Elimination half-lives of benzodiazepines and active metabolites in . The half-life of diazepam increases with age. Diazepam has a short half-life in dogs ( h) compared with cats (–20 h). Additionally, its active metabolite nordiazepam also has a short half-life in dogs (3 h. The primary metabolite of diazepam, desmethyldiazepam, is also pharmacologically active, and its half-life exceeds that of diazepam. The metabolism of. Time course of antirecall effect of diazepam and lorazepam following oral administration. Diazepam is avoided in neonates and infants because of its prolonged half-life. Diazepam Valium is among metabolites most successful drugs from the onset journal the psychopharmacological revolution valium began during the half. Elimination valium doses for anxiety is an estimate of the time needed to reduce the drug concentration in the plasma by half. Life 10 January